ABSTRACT
The objective of the study was to investigate the nephroprotective activity of methanolic extract of different morphological parts [bract, flower, trachea and tracheal fluid] of Musa paradisiaca L. [Family: Musaceae] against gentamicin-induced nephrotoxicity in mice. Gentamicin produced significant changes in biochemical [increased levels of blood urea nitrogen level, blood urea, and serum creatinine], and histological parameters in mice. Treatment with methanolic extract of bract [100 and 250mg/kg, b.w] and flowering stalk [trachea] [250 and 500mg/kg, b.w] significantly prevented biochemical and histological changes produced by gentamicin toxicity. The extracts of M. paradisiaca[bract and flowering stalk] could contribute a lead to discovery of a new drug for the treatment of drug-induced nephrotoxicity
ABSTRACT
Tribulus terrestris extracts were prepared using solvents of different polarities and their irritant inducing effects were assessed in vivo on rabbit's ears
The result indicates that the polar components were in higher yield than the others and amounts of the extracted material were directly proportional to the polarities of solvents. Preliminary phytochemical screening shows diversity of compounds and comparative TLC analytical behaviour further indicated the resolution of mostly five compounds from the non-polar, intermediate polar and highly polar materials by different solvent systems. Irritant potency of water extract was assessed on rabbit's ears using a known method that was proved to be the most potent irritant [with +++ response, propagated in an area of 2.70 cm[2] diameter]
ABSTRACT
Objective of the present study was to observe plasma lipid profile [triglycerides, cholesterol, LDL-cholesterol and HDL-cholesterol] in sarcoma patients. 120 subjects were included in the project. The subjects comprised of two groups; first as Controls [60 in number] and the second as Patients of Sarcoma [also 60 in number]. Fasting blood samples were collected for estimation. Sarcoma patients showed highly significant [P<0.01] decrease, when compared with the normal control subjects